Being pluripotent VSELs express nuclear OCT-4 which is usually no longer required to maintain the pluripotent state, shifts to the cytoplasm in the immediate descendants SSCs and eventually disappears upon further differentiation. Correct meiotic progression has remained the major bottle-neck and various groups have used chemicals like retinoic acid for … Continue reading Being pluripotent VSELs express nuclear OCT-4 which is usually no longer required to maintain the pluripotent state, shifts to the cytoplasm in the immediate descendants SSCs and eventually disappears upon further differentiation